C81 ROLE OF RESTRICTIVE DIASTOLIC DYSFUNCTION FOR RISK STRATIFICATION OF PATIENTS WITH HYPERTROPHIC CARDIOMYOPATHY: A BAYESIAN MODEL AVERAGING

Abstract Background Hypertrophic cardiomyopathy (HCM) is characterized by increased left ventricular (LV) stiffness, leading to raised filling pressures and restrictive diastolic dysfunction (RDD), in itself independently associated with an risk of a clinical deterioration. We assessed whether echocardiography evaluation function HCM could yield prognostic value be useful stratification. Methods retrospectively reviewed imaging (echocardiography cardiovascular magnetic resonance, CMR) data from 361 consecutive patients two Italian referral centers (Mauriziano Hospital, Turin; University Hospital Trieste, Trieste). Among them, 28 were classified after Doppler examination as (E/A > 1.5, DecT E < 140 ms, E/e’ 10). The primary endpoint was large composite consisting sudden cardiac death (SCD), major arrythmias (MVAs), heart transplant (HT) hospitalization for failure (HF). Other secondary endpoints investigated follows: 1) arrhythmic SCD MVAs, 2) key HF, HT, non–SCD. A Bayesian Model Averaging (BMA) then performed overcome the bias determined limited number observations. Results Over mean follow up 7 ± 3 years, 61 (17%) experienced at least one event. Of 10 identified pattern. When BMA performed, late gadolinium enhancement (LGE) presence CMR RDD significantly outcome (respectively, PI = 100, HR 3.55, pd 1.00; 74.5, 3.33, 0.99). Left atrium (LA) diameter not strongly endpoint, whereas it outcome, well (E/e’) 94.5, 1.10, 86.8, 1.08, Conclusions Restrictive independent predictor poor prognosis early stages absence systolic dysfunction. In particular, predicted outcomes related better LA E/e’.